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European Meeting on Molecular Diagnostics
October 12 – 14, 2011
Kurhaus Hotel, Scheveningen, the Netherlands
Wednesday October 12, 2011
13.00 – 13.15 OPENING EMMD 2011
Session 1 13:15 – 15:15
MOLECULAR DIAGNOSTICS IN CLINICAL MICROBIOLOGY
Chair: Prof J. Schrenzel MD & t.b.a.
13:15 – 14:00 Keynote: Rapid detection of Sepsis
Prof J. Schrenzel MD
Geneva University Hospitals - Division of Infectious Diseases,
Switzerland
14:00 – 14:15 Multicenter evaluation of a novel non-enzymatic method for enrichment
of pathogenDNA from large volumes of whole blood
Mrs. Bos M.P.*, Mrs. Loonen A, van Meersbergen B, Catsburg A,
Savelkoul P, van den Brule A, Neerken S, van de Wiel P
Laboratorium voor Moleculaire Diagnostiek, Jeroen Bosch Ziekenhuis,
’s-Hertogenbosch
Philips Research, Department of Molecular Diagnostics, Eindhoven
Department of Medical Microbiology and Infection Control, VU Medical
Center, Amsterdam and Microbiome Ltd., Houten
14:15 – 14:30 Molecular Characterization of STEC-Isolates collected during the E.coli
O104:H4 outbreak in Germany
Guido Adler, Sabine Raith, Thomas Laue, Markus Hess*
astra Diagnostics GmbH, Hamburg, Germany
14:30 – 14:45 TRS-PCR genotyping of intracellular pathogens – Salmonella enterica
serovars
Anna Krzyzanowska*, Marta Majchrzak, Anna B. Kubiak, Arkadiusz
Wojtasik, Pawel Parniewski
Institute of Medical Biology, Lodz Poland
14:45 – 15.15 Rapid molecular analysis of complex microbial communities
Prof. Dr. P. Savelkoul
VU Medical Centre Amsterdam, the Netherlands
Coffee break + Posters 15:15 – 15:45
GUEST LECTURES 15:45 – 17:15
15:45 – 16:30 Forensics and Molecular Diagnostics
Prof. Dr. P. de Knijff
Leiden University Medical Centre, Human Genetic, the Netherlands
16:30 – 17:15 HPV and cervical cancer: pathogenesis and implications for cervical
screening
Prof. Dr. P.J.F. Snijders
Dept. of Pathology, VU University medical center, Amsterdam
SOCIAL PROGRAM:
17:30 – 19:00 Welcome reception at La Galleria, Boulevard Scheveningen
Thursday October 13, 2011
Session 2 09.00 – 10.45
MOLECULAR DIAGNOSTICS IN PATHOLOGY AND CLINICAL GENETICS
Chair: Prof. dr. E. Cuppen & Dr. H.G. Yntema
09:00 – 09:45 Keynote: Thousand dollar genomes and million dollar questions
Prof. dr. E. Cuppen
University Medical Center Utrecht, Netherlands
09:45 – 10:15 NGS (next generation sequencing); informed consent issues
Dr. H.G. Yntema
Department of Human Genetics, Radboud University Nijmegen Medical
Centre, The Netherlands
10:15 – 10:30 Genome-wide analysis of CpG island methylation in bladder cancer
identifies novel biomarkers for diagnosis and prediction of progression
Raju Kandimalla*, Angela A. G. van Tilborg, Lucie C. Kompier,
Dominique J.P.M Stumpel, Chris H. Bangma, Ellen C. Zwarthoff
Erasmus medical center Department of pathology Rotterdam,
The Netherlands
Erasmus medical center Department of pediatric oncology Rotterdam,
The Netherlands
Erasmus medical center Department of urology Rotterdam, The Netherlands
10:30 – 10:45 SNP array for rapid prenatal diagnosis
M. Srebniak, M. Boter, G. Oudesluijs, M. Joosten, L. Govaerts,
K. Diderich, T. Cohen-Overbeek, M. Knapen, R-J. H. Galjaard
Erasmus MC, Rotterdam, The Netherlands
Coffee break + Posters 10.45 – 11.15
Session 3 11.15 – 12.30
QUALITY CONTROL AND AUTOMATION
Chair: MSc. M.H.J. Molijn & t.b.a.
11.15 – 12.00 Keynote: Preventing medication errors by closing the information loop
with a new PDA application
MSc. M.H.J. Molijn
van de Geijn Partners, The Netherlands
12.00 – 12.15 The impact of thermocycler variability on molecular diagnostics
M. Span*, M.T.M. Hendrikx, M.A.W. Verblakt
CYCLERtest B.V., Langraaf, The Netherlands
12.15 – 12.30 Evaluation of different assays for the detection of influenza A, A(H1N1)
v2009 and B in Belgian hospital laboratories
Raymaekers M.* (Jessa Ziekenhuis Hasselt), Bogaerts P. (CHU Mont-
Godinne Yvoir), Descheemaeker P. (AZ Sint-Jan Brugge-Oostende),
Duson G. (Imelda ziekenhuis Bonheiden), Martens K. (Ziekenhuis
Oost Limburg Genk), Meex C. (CHU Liège), Reynders M. (CHU St
Pierre, Bruxelles), Soetens O. (UZ Brussel), Ursi D. (UZA Antwerpen),
Vaeyens F. (OLV ziekenhuis Aalst), Vanmassenhove B. (AZ Damiaan
Oostende), Verstrepen W. (ZNA Antwerpen), Boone E.
(H.-Hartziekenhuis Roeselare-Menen)
On behalf of MolecularDiagnostics.be, Belgium
Lunch + Posters12.30 – 14.00
Session 4 14.00 – 15:45
MOLECULAR DIAGNOSTICS IN VIROLOGY
Chair: Prof. Dr. M. van Ranst & t.b.a.
14:00 – 14:45 Keynote: Molecular Diagnostics in Virology
Prof. Dr. M. Van Ranst
Catholic University Leuven, Belgium
14:45 – 15:00 High Resolution Melting Curve Genotyping of IL28B SNPs Associated
with Hepatitis C Virus Clearance and Therapy Response
Richard Molenkamp, Sylvie Koekkoek, Janke Schinkel
Department of Medical Microbiology Academic Medical Center
Amsterdam, The Netherlands
15:00 – 15:15 Development of specific real-time RT-PCR assays for entero- and
rhinovirus using a one-step RNA Master Mix
J.J.C.Voermans, J.Anber, J.Beverdam, A.van der Zanden,
M.Schutten, S.D.Pas*
Department of Virology, ErasmusMC Rotterdam, the Netherlands
Laboratorium Microbiologie TA, Enschede, the Netherlands
15:15 – 15.30 More than five year epidemiological data of 15 respiratory viruses in an
academic hospital in The Netherlands
Els Wessels* Kate Templeton, Ann Vossen, Mariet Feltkamp, Louis
Kroes, Eric Claas
Leiden University Medical Center Department of Medical
Microbiology, Leiden The Netherlands
15:30 – 15:45 Clinical Relevance in Molecular Diagnostics: What do we know?
Noortje M van Maarseveen*, Anton M van Loon, Frans Verduyn
Lunel, Rob Schuurman
University Medical Center Utrecht, The Netherlands
POSTER SESSION PLUS INFORMAL GATHERING : 15:45 – 18:30
15:45 – 16:15 Member meeting VMDG (invited members only)
SOCIAL PROGRAM:
19.00 – 22.00 Conference dinner at Crazy Piano’s, Strandweg Scheveningen
(below the Kurhaus)
Friday October 14, 2011
Session 5 09.00 – 11.00
MOLECULAR DIAGNOSTICS IN COMPANIES FUTURE VISION
09:00 – 09:30 The Changing Landscape in Molecular Diagnostics
Roche Diagnostics, Mr. Terry J. Fetterhoff
09:30 – 10:00 From Probes to Personalized Medicine: A Perspective on Future
Applications of Molecular Diagnostics
Abbott Molecular Inc., Dr. E. Patrick Groody
10:00 – 10:20 Bridging clinician’s needs and laboratory services
BD Diagnostics, Steve Clark / Herbert Torfs
10:20 – 10:40 QIAGEN’s vision of future molecular diagnostics
Qiagen, Olivier Pasquier.
10:40 – 11:00 Molecular Diagnostics Future Vision
Focus Diagnostics, Maurice Exner, PhD
Coffee break + Posters 11.00 – 11.30
INVITED LECTURE:
11:30 – 12:15 Past, present and future of human molecular diagnostics; focus on
microbiology
Prof. Alex van Belkum, the Netherlands
Lunch + Posters12.15 – 13:45
Session 6 13:45 – 16.30
NEW TECHNOLOGIES IN MDx
Chair: Prof. W. Ansorge & t.b.a.
13:45 – 14:30 Keynote: Next generation sequencing technologies in molecular
diagnostics
Prof. W. Ansorge
École polytechnique fédérale de Lausanne, Switzerland
14.30 – 14:45 High Throughput MLST - Bringing Molecular Typing to the Next Level
Boers, S.A.*, van der Reijden, W.A., Jansen, R
Regional Laboratory of Public Health, Haarlem, The Netherlands
14:45 – 15:00 High-resolution breath analysis and volatile biomarker (VOCs) in
patients with cystic fibrosis
Rolf Kramer*, Manfred Höfle, Wolf-Rainer Abraham
Department of Vaccinology and Applied Microbiology, Helmholtz
Centre for Infection Research (HZI), Braunschweig, Germany
15:00 – 15:15 Epidemiological Studies of Upper Respiratory Infections Using
Simultaneous Detection and Definitive Identification of Pathogens
by Resequencing Microarrays
Agnieszka M Lichanska*, Matthew C. Lorence, Lisa A. Borsuk, Klaus
Schafer, Brian Weslowski, Clark Tibbetts
TessArae, Sterling, VA, USA
15:15 – 15:30 Rapid identification of infectious pathogens with PCR-Electrospray-
Ionization Time-of-Flight Mass Spectrometry
Dr. Carsten Tiemann, Dipl. Biol. Andrea Hartmann, Dipl.Biol. Daniela
Knoop, Christoph Busse
Labor Krone Medical-Investigation-Center LABCON OWL GmbH,
Bad Salzuflen Germany
IMOLTEC Institute for Instrumental and Molecular Technologies,
University of Applied Sciences Bielefeld, Bad Salzuflen, Germany
15:30 – 15:45 Discriminating major methicillin-resistant Staphylococcus aureus
lineages using MALDI-TOF MS
Kevin Martens, Sylvia Tielens, Guy Coppens, Els Oris
Labo voor moleculaire diagnostiek Ziekenhuis Oost Limburg, Genk,
Belgium
15.45 – 16:15 The role of increasing innovations in Molecular Diagnostics: Medical
Value
Mr. Terry J. Fetterhoff
Roche Diagnostics, USA
16:15 CLOSURE OF MEETING AND FINAL REMARKS
End of 7th European Meeting on Molecular Diagnostics
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